Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria.

@article{Salanti2003SelectiveUO,
  title={Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria.},
  author={Ali Salanti and Trine Staalsoe and Thomas Lavstsen and Anja T R Jensen and M P Kordai Sowa and David E. Arnot and Lars Hviid and Thor G. Theander},
  journal={Molecular microbiology},
  year={2003},
  volume={49 1},
  pages={179-91}
}
Cytoadhesion of infected red blood cells (iRBC) is mediated through parasite-encoded, clonally variant surface antigens (VSA) and is a central process in the pathogenesis of Plasmodium falciparum malaria. Pregnancy-associated malaria (PAM) has been linked to VSA-mediated adhesion of iRBC to the glycosaminoglycan chondroitin sulphate A (CSA) in the placental intervillous space. Several studies have pointed to members of the PfEMP1 VSA family as mediators of CSA-specific iRBC sequestration in the… CONTINUE READING
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