Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents.

@article{Berk1999SelectiveUO,
  title={Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents.},
  author={Paul C. M. van den Berk and Sen Lin Zhou and C L Kiang and Decherd D. Stump and Xingjun Fan and Michael W. Bradbury},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 40},
  pages={
          28626-31
        }
}
Long chain fatty acid transport is selectively up-regulated in adipocytes of Zucker fatty rats, diverting fatty acids from sites of oxidation toward storage in adipose tissue. To determine whether this is a general feature of obesity, we studied [(3)H]oleate uptake by adipocytes and hepatocytes from 1) homozygous male obese (ob), diabetic (db), fat (fat), and tubby (tub) mice and from 2) male Harlan Sprague-Dawley rats fed for 7 weeks a diet containing 55% of calories from fat. V(max) and K(m… CONTINUE READING
Highly Cited
This paper has 35 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Lipid metabolism and liver inflammation. I. Hepatic fatty acid uptake: possible role in steatosis.

American journal of physiology. Gastrointestinal and liver physiology • 2006
View 4 Excerpts
Highly Influenced

Changes in fatty acid transport and transporters are related to the severity of insulin deficiency.

American journal of physiology. Endocrinology and metabolism • 2002
View 4 Excerpts
Highly Influenced