Selective up-regulation of cytokine-induced RANTES gene expression in lung epithelial cells by overexpression of IkappaBR.

@article{Ray1997SelectiveUO,
  title={Selective up-regulation of cytokine-induced RANTES gene expression in lung epithelial cells by overexpression of IkappaBR.},
  author={P Bambha Ray and Liqun Yang and Daguang Zhang and Salil K Ghosh and Alpana Ray},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 32},
  pages={
          20191-7
        }
}
We previously reported the cloning of a cDNA for IkappaBR (for IkappaB-related) from human lung alveolar epithelial cells. IkappaBR is related to the IkappaB proteins that function as regulators of the NF-kappaB family of transcription factors. Here, we investigated the consequence of IkappaBR overexpression on the expression of NF-kappaB-regulated chemokine genes in lung alveolar epithelial cells. Chemokines play an important role in many inflammatory diseases such as asthma and AIDS… CONTINUE READING
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