Selective uncoupling of G alpha 12 from Rho-mediated signaling.

@article{Meigs2005SelectiveUO,
  title={Selective uncoupling of G alpha 12 from Rho-mediated signaling.},
  author={Thomas E. Meigs and Juhi Juneja and Christopher DeMarco and Laura N. Stemmle and Daniel D. Kaplan and Patrick J. Casey},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 18},
  pages={18049-55}
}
The heterotrimeric G protein G(12) has been implicated in such cellular regulatory processes as cytoskeletal rearrangement, cell-cell adhesion, and oncogenic transformation. Although the activated alpha-subunit of G(12) has been shown to interact directly with a number of protein effectors, the roles of many of these protein-protein interactions in G(12)-mediated cell physiology are poorly understood. To begin dissecting the specific cellular pathways engaged upon G(12) activation, we produced… CONTINUE READING
Highly Cited
This paper has 22 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…