Selective turnover and shedding of H-2K and H-2D antigens is controlled by the major histocompatibility complex. Implications for H-2- restricted recognition

@article{Emerson1980SelectiveTA,
  title={Selective turnover and shedding of H-2K and H-2D antigens is controlled by the major histocompatibility complex. Implications for H-2- restricted recognition},
  author={Stephen G Emerson and Donal B. Murphy and Robert E. Cone},
  journal={The Journal of Experimental Medicine},
  year={1980},
  volume={152},
  pages={783 - 795}
}
Lactoperoxidase-catalyzed cell surface radioiodination and incorporation of [3H]-leucine were employed to radiolabel H-2K and H-2D antigens of murine spleen cells. The fate of H-2 antigens was monitored by in vitro culture of labeled cells and isolation of labeled antigens from detergent lysates of the cells and culture supernates obtained at different times during culture. H-2Kk antigens were found to be rapidly turned over and shed by CBA/J cells, whereas the turnover of H-2Dk antigens was… CONTINUE READING
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