Selective transplantation of rods delays cone loss in a retinitis pigmentosa model.

@article{MohandSaid2000SelectiveTO,
  title={Selective transplantation of rods delays cone loss in a retinitis pigmentosa model.},
  author={Saddek Mohand-Said and David W. Hicks and Henri Dreyfus and Jos{\'e} Alain Sahel},
  journal={Archives of ophthalmology},
  year={2000},
  volume={118 6},
  pages={807-11}
}
BACKGROUND Rod-cone retinal degenerations (retinitis pigmentosa) are typified by initial rod loss followed by secondary cone death. Rod death, predominantly caused by gene mutations expressed specifically in these cells, induces scotopic vision loss. Cone death, the overriding cause of blindness, has no current explanation. Disease progression and preliminary data suggest that cone survival depends on rods. OBJECTIVE To establish whether rod transplantation into mutant rodless retinas could… CONTINUE READING
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