Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants.

@article{Wolinsky1992SelectiveTO,
  title={Selective transmission of human immunodeficiency virus type-1 variants from mothers to infants.},
  author={Steven M. Wolinsky and C M Wike and Bette T Korber and Cecelia Hutto and Wade P. Parks and Lisa L. Rosenblum and Kevin J. Kunstman and Manohar R Furtado and Jos{\'e} L. Mu{\~n}oz},
  journal={Science},
  year={1992},
  volume={255 5048},
  pages={1134-7}
}
Multiple human immunodeficiency virus type-1 sequences from the V3 and V4-V5 regions of the envelope gene were analyzed from three mother-infant pairs. The infants' viral sequences were less diverse than those of their mothers. In two pairs, a proviral form infrequently found in the mother predominated in her infant. A conserved N-linked glycosylation site within the V3 region, present in each mother's sequence set, was absent in all of the infants' sequence sets. These findings demonstrate… CONTINUE READING
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