Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis.

@article{Fitzner2011SelectiveTO,
  title={Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis.},
  author={Dirk Fitzner and Mareike Schnaars and Denise van Rossum and Gurumoorthy Krishnamoorthy and Payam Dibaj and Mostafa Bakhti and Tommy Regen and U. -K Hanisch and Mikael Simons},
  journal={Journal of cell science},
  year={2011},
  volume={124 Pt 3},
  pages={
          447-58
        }
}
The transfer of antigens from oligodendrocytes to immune cells has been implicated in the pathogenesis of autoimmune diseases. Here, we show that oligodendrocytes secrete small membrane vesicles called exosomes, which are specifically and efficiently taken up by microglia both in vitro and in vivo. Internalisation of exosomes occurs by a macropinocytotic mechanism without inducing a concomitant inflammatory response. After stimulation of microglia with interferon-γ, we observe an upregulation… CONTINUE READING

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