Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis

  title={Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis},
  author={Arianna Sab{\`o} and Theresia Kress and Mattia Pelizzola and Stefano de Pretis and Marcin M. Gorski and Alessandra Tesi and Marco J. Morelli and Pranami Bora and Mirko Doni and Alessandro Verrecchia and Claudia Tonelli and Giovanni Fag{\'a} and Valerio Bianchi and Alberto Ronchi and Diana H. P. Low and Heiko M{\"u}ller and Ernesto Guccione and Stefano Campaner and Bruno Amati},
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and downregulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed ‘invasion’) and acts as a general amplifier of transcription. However, the available data did not readily discriminate between direct and indirect effects of Myc on RNA biogenesis. We addressed this issue with genome-wide… CONTINUE READING
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