Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis

  title={Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis},
  author={A. Sab{\`o} and Theresia R. Kress and Mattia Pelizzola and S. D. Pretis and Marcin M. Gorski and A. Tesi and M. J. Morelli and Pranami Bora and M. Doni and A. Verrecchia and C. Tonelli and G. Fag{\'a} and V. Bianchi and A. Ronchi and D. Low and H. M{\"u}ller and E. Guccione and S. Campaner and B. Amati},
  • A. Sabò, Theresia R. Kress, +16 authors B. Amati
  • Published 2014
  • Biology, Medicine
  • Nature
  • The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and downregulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed ‘invasion’) and acts as a general amplifier of transcription. However, the available data did not readily discriminate between direct and indirect effects of Myc on RNA biogenesis. We addressed this issue with genome-wide… CONTINUE READING
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