Selective toxicity of the anthelmintic emodepside revealed by heterologous expression of human KCNMA1 in Caenorhabditis elegans.

@article{Crisford2011SelectiveTO,
  title={Selective toxicity of the anthelmintic emodepside revealed by heterologous expression of human KCNMA1 in Caenorhabditis elegans.},
  author={Anna Crisford and Caitriona Murray and Vincent O'Connor and Richard J. Edwards and Nina Kruger and Claudia Welz and Georg von Samson-Himmelstjerna and Achim Harder and Robert J. Walker and Lindy Holden-Dye},
  journal={Molecular pharmacology},
  year={2011},
  volume={79 6},
  pages={1031-43}
}
Emodepside is a resistance-breaking anthelmintic of a new chemical class, the cyclooctadepsipeptides. A major determinant of its anthelmintic effect is the calcium-activated potassium channel SLO-1. SLO-1 belongs to a family of channels that are highly conserved across the animal phyla and regulate neurosecretion, hormone release, muscle contraction, and neuronal network excitability. To investigate the selective toxicity of emodepside, we performed transgenic experiments in which the nematode… CONTINUE READING