Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells.

@article{Singh2001SelectiveTO,
  title={Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells.},
  author={N. P. Singh and Huang Lai},
  journal={Life sciences},
  year={2001},
  volume={70 1},
  pages={
          49-56
        }
}
  • N. Singh, H. Lai
  • Published 1 November 2001
  • Chemistry, Medicine
  • Life sciences
Artemisinin becomes cytotoxic in the presence of ferrous iron. [...] Key Result We report here that after incubation with holotransferrin, which increases the concentration of ferrous iron in cancer cells, dihydroartemisinin, an analog of artemisinin, effectively killed a type of radiation-resistant human breast cancer cell in vitro. The same treatment had considerably less effect on normal human breast cells. Since it is relatively easy to increase the iron content inside cancer cells in vivo, administration…Expand
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