Selective toxicity and enhanced therapeutic index of liposomal polyene antibiotics in systemic fungal infections.

@article{Juliano1985SelectiveTA,
  title={Selective toxicity and enhanced therapeutic index of liposomal polyene antibiotics in systemic fungal infections.},
  author={Rudolph L Juliano and Gabriel L{\'o}pez-Berestein and R. L. Hopfer and Rajan Mehta and Kapil Mehta and Karen A. Mills},
  journal={Annals of the New York Academy of Sciences},
  year={1985},
  volume={446},
  pages={390-402}
}
Incorporation of the polyene antibiotic amphotericin B (AMB) in liposomes results in a marked reduction in drug toxicity with no loss of antifungal potency. Nephrotoxicity, the dose-limiting side effect of AMB, is almost abolished when the drug is utilized in a liposomal carrier. Because of reduced toxicity, high doses of liposomal AMB can be used, resulting in superior therapy of systemic fungal infections in mice. The improved therapeutic index of liposomal AMB versus free AMB is also… CONTINUE READING