Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design.

@article{Aronov1998SelectiveTB,
  title={Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design.},
  author={Alex M. Aronov and Christophe L. M. J. Verlinde and Wim G. J. Hol and Michael H. Gelb},
  journal={Journal of medicinal chemistry},
  year={1998},
  volume={41 24},
  pages={
          4790-9
        }
}
  • Alex M. Aronov, Christophe L. M. J. Verlinde, +1 author Michael H. Gelb
  • Published 1998
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from the sleeping sickness parasite Trypanosoma brucei is a rational target for anti-trypanosomatid drug design because glycolysis provides virtually all of the energy for the bloodstream form of this parasite. Glycolysis is also an important source of energy for other pathogenic parasites including Trypanosoma cruzi and Leishmania mexicana. The current study is a continuation of our efforts to use the X-ray structures of T. brucei and L… CONTINUE READING

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    Structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma brucei determined from Laue data.

    Prospects for Antiparasitic Drugs