Selective thymocyte depletion in neonatal HIV-1 thymic infection.


OBJECTIVE To determine the impact of HIV-1 infection on thymocyte development, and the role of thymic infection on the pathogenesis of neonatal HIV-1 infection. DESIGN AND METHODS The consequences of thymic infection by HIV-1 were examined by comparative histologic and molecular analyses of an asymptomatic, HIV-1-seropositive 3-day-old subject, versus age… (More)