Selective targeting to the hyperactive beta-catenin/T-cell factor pathway in colon cancer cells.

@article{Chen2001SelectiveTT,
  title={Selective targeting to the hyperactive beta-catenin/T-cell factor pathway in colon cancer cells.},
  author={R H Chen and Frank Mccormick},
  journal={Cancer research},
  year={2001},
  volume={61 11},
  pages={4445-9}
}
Many colon cancers suffer mutations in either the adenomatous polyposis coli or beta-catenin genes that lead to stabilization of beta-catenin and activation of downstream T-cell factor (Tcf) target genes. We have developed a novel approach targeting colon cancer cells based on their aberrant beta-catenin/Tcf signaling pathway. A recombinant adenovirus, in which an apoptosis gene fadd is under the control of the promoter containing Tcf-responsive elements, selectively and efficiently kills colon… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…