Selective targeting of tumoral vasculature: comparison of different formats of an antibody (L19) to the ED-B domain of fibronectin.

@article{Borsi2002SelectiveTO,
  title={Selective targeting of tumoral vasculature: comparison of different formats of an antibody (L19) to the ED-B domain of fibronectin.},
  author={Laura Borsi and Enrica Balza and Marco Bestagno and Patrizia Castellani and Barbara Carnemolla and Attila Bir{\`o} and Alessandra Leprini and Jorge Gonz{\'a}lez Sep{\'u}lveda and Oscar R Burrone and Dario Neri and Luciano Zardi},
  journal={International journal of cancer},
  year={2002},
  volume={102 1},
  pages={75-85}
}
We recently demonstrated that a human recombinant scFv, L19, reacting with the ED-B domain of fibronectin, a marker of angiogenesis, selectively targets tumoral vasculature in vivo. Using the variable regions of L19, we constructed and expressed a human "small immunoprotein" (SIP) and a complete human IgG1 and performed biodistribution studies in tumor-bearing mice to compare the blood clearance rate, in vivo stability and performance in tumor targeting of the 3 L19 formats [dimeric scFv (scFv… CONTINUE READING

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