Selective targeting of the stress chaperome as a therapeutic strategy.

@article{Taldone2014SelectiveTO,
  title={Selective targeting of the stress chaperome as a therapeutic strategy.},
  author={Tony Taldone and Stefan O. Ochiana and Pallav D. Patel and Gabriela Chiosis},
  journal={Trends in pharmacological sciences},
  year={2014},
  volume={35 11},
  pages={
          592-603
        }
}
Normal cellular function is maintained by coordinated proteome machinery that performs a vast array of activities. Helping the proteome in such roles is the chaperome, a network of molecular chaperones and folding enzymes. The stressed cell contains, at any time, a complex mixture of chaperome complexes; a majority performs 'housekeeping functions' similarly to non-stressed, normal cells, but a finely-tuned fraction buffers the proteome altered by chronic stress. The stress chaperome is… CONTINUE READING

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