Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1

@inproceedings{Francipane2013SelectiveTO,
  title={Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1},
  author={Maria Giovanna Francipane and Eric Lagasse},
  booktitle={Oncotarget},
  year={2013}
}
Metastatic colorectal cancer (CRC) is incurable for most patients. Since mammalian target of rapamycin (mTOR) has been suggested as a crucial modulator of tumor biology, we aimed at evaluating the effectiveness of mTOR targeting for CRC therapy. To this purpose, we analyzed mTOR expression and the effect of mTOR inhibition in cancer stem-like cells isolated from three human metastatic CRCs (CoCSCs). CoCSCs exhibited a strong mTOR complex 2 (mTORC2) expression, and a rare expression of mTOR… CONTINUE READING