Selective sweep on human amylase genes postdates the split with Neanderthals

  title={Selective sweep on human amylase genes postdates the split with Neanderthals},
  author={Charlotte E. Inchley and Cynthia D. A. Larbey and Nzar A. A. Shwan and Luca Pagani and Lauri Saag and Tiago Antao and Guy S Jacobs and Georgi Hudjashov and Ene Metspalu and Mario Mitt and Christina A. Eichstaedt and B. A. Malyarchuk and Miroslava V. Derenko and J. T. K. Wee and Syafiq Abdullah and Francois-Xavier Ricaut and Maru Mormina and Reedik M{\"a}gi and Richard Villems and Mait Metspalu and Martin K. Jones and John A. L. Armour and Toomas Kivisild},
  booktitle={Scientific reports},
Humans have more copies of amylase genes than other primates. It is still poorly understood, however, when the copy number expansion occurred and whether its spread was enhanced by selection. Here we assess amylase copy numbers in a global sample of 480 high coverage genomes and find that regions flanking the amylase locus show notable depression of genetic diversity both in African and non-African populations. Analysis of genetic variation in these regions supports the model of an early… CONTINUE READING
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