Selective sweep mapping of genes with large phenotypic effects.

@article{Pollinger2005SelectiveSM,
  title={Selective sweep mapping of genes with large phenotypic effects.},
  author={John P Pollinger and Carlos Daniel Bustamante and Adi Fledel-Alon and Sheila M. Schmutz and Melissa M. Gray and Robert K. Wayne},
  journal={Genome research},
  year={2005},
  volume={15 12},
  pages={1809-19}
}
Many domestic dog breeds have originated through fixation of discrete mutations by intense artificial selection. As a result of this process, markers in the proximity of genes influencing breed-defining traits will have reduced variation (a selective sweep) and will show divergence in allele frequency. Consequently, low-resolution genomic scans can potentially be used to identify regions containing genes that have a major influence on breed-defining traits. We model the process of breed… CONTINUE READING

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