Selective suppression of hippocampal ripples impairs spatial memory

@article{Girardeau2009SelectiveSO,
  title={Selective suppression of hippocampal ripples impairs spatial memory},
  author={Gabrielle Girardeau and Karim Benchenane and Sidney I. Wiener and Gy{\"o}rgy Buzs{\'a}ki and Micha{\"e}l Zugaro},
  journal={Nature Neuroscience},
  year={2009},
  volume={12},
  pages={1222-1223}
}
Sharp wave–ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment in rats trained on a hippocampus-dependent spatial memory task. Our results provide evidence for a prominent role of hippocampal SPW-Rs in memory consolidation. 

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