Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis

@article{Leviar2003SelectiveSO,
  title={Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis},
  author={Nata{\vs}a Levi{\vc}ar and Ricardo A. Dewey and Emma Daley and Timothy E. Bates and Derek Davies and Janko Kos and Geoffrey J. Pilkington and Tamara T Lah},
  journal={Cancer Gene Therapy},
  year={2003},
  volume={10},
  pages={141-151}
}
Invasion and metastasis of certain tumors are accompanied by increased mRNA protein levels and enzymatic activity of cathepsin L. Cathepsin L has also been suggested to play a role in the proteolytic cascades associated with apoptosis. To investigate the role of cathepsin L in brain tumor invasion and apoptosis, the human glioma cell line, IPTP, was stably transfected with full-length antisense and sense cDNA of cathepsin L. Down-regulation of cathepsin L by antisense cDNA significantly… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 49 references

Lysosomal enzymes, cathepsins in glioma invasion

N Levičar, T Strojnik, J Kos
J Neuro-Oncol • 2002

Neuronal loss and brain atrophy in mice lacking cathepsins B and L.

Proceedings of the National Academy of Sciences of the United States of America • 2002

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