Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists.

@article{Mori2007SelectiveSO,
  title={Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists.},
  author={Akio Mori and Koji Ogawa and Koichiro Someya and Yuichi Kunori and Daisuke Nagakubo and Osamu Yoshie and Fujiko Kitamura and Takachika Hiroi and Osamu Kaminuma},
  journal={International immunology},
  year={2007},
  volume={19 8},
  pages={913-21}
}
The effects of selective CC chemokine receptor (CCR)-3 antagonists on antigen-induced leukocyte accumulation in the lungs of mice adoptively transferred with in vitro-differentiated T(h)1 and T(h)2 were investigated. Inhalation of antigen by mice injected with T(h)1 and T(h)2 initiated the migration of T cells themselves into the lungs. Subsequently, neutrophils massively accumulated in T(h)1-transferred mice, whereas eosinophil infiltration was specifically induced by T(h)2. CCR3 antagonists… CONTINUE READING
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