Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis.

@article{Cowart2007SelectiveSS,
  title={Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis.},
  author={L. Ashley Cowart and Yusuf A. Hannun},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 16},
  pages={12330-40}
}
The heat stress response of Saccharomyces cerevisiae is characterized by transient cell cycle arrest, altered gene expression, degradation of nutrient permeases, trehalose accumulation, and translation initiation of heat shock proteins. Importantly heat stress also induces de novo sphingolipid synthesis upon which many of these subprograms of the heat stress response depend. Despite extensive data addressing the roles for sphingolipids in heat stress, the mechanism(s) by which heat induces… CONTINUE READING