Selective stimulation of carboxylesterases metabolizing charged steroid esters by hydrocortisone.

Abstract

We observed a remarkable augmentation in the rate of hydrolytic breakdown of HCHS following exposure to corticosteroid therapy. This underscores the need for a careful reappraisal of its dosage in long term therapy. In such an event the uncharged ester may be the preferred drug of choice. 

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Cite this paper

@article{Kaur1991SelectiveSO, title={Selective stimulation of carboxylesterases metabolizing charged steroid esters by hydrocortisone.}, author={S Kaur and Parul Khanna and Surendra S. Parmar and Basheer Ali}, journal={Biochemical pharmacology}, year={1991}, volume={41 3}, pages={476-8} }