Selective stabilization of microtubules within the proximal region of developing axonal neurites.

@article{Shea1999SelectiveSO,
  title={Selective stabilization of microtubules within the proximal region of developing axonal neurites.},
  author={Thomas B. Shea},
  journal={Brain research bulletin},
  year={1999},
  volume={48 3},
  pages={255-61}
}
This study examined the distribution of labile and stable microtubules (MTs) during axonal neurite elaboration in NB2a/d1 cells using immunocytochemical markers of unmodified (tyrosinated; Tyr), modified (detyrosinated [Glu] and acetylated [Acet]) and total tubulin. Prominent total and Tyr tubulin immunoreactivity was relatively evenly distributed throughout axonal neurites. By contrast, Acet or Glu immunoreactivity was relatively concentrated within the proximal region of the neurite… CONTINUE READING