Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney.

@article{Awad2006SelectiveS1,
  title={Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney.},
  author={Alaa Shihan Awad and Hong Ye and Liping Huang and Li Li and Frank W Foss and Timothy L. Macdonald and Kevin R Lynch and Mark Douglas Okusa},
  journal={American journal of physiology. Renal physiology},
  year={2006},
  volume={290 6},
  pages={
          F1516-24
        }
}
The mechanisms involved in renal ischemia-reperfusion injury (IRI) are complex and appear to involve the early participation of bone marrow-derived cells. T lymphocytes participate in the pathogenesis of IRI. Sphingosine 1-phosphate (S1P) induces peripheral T cell depletion. Therefore, we hypothesized that S1P1 receptor activation protects kidney from IRI. FTY-720, a non-receptor-selective sphingosine analog, was given intraperitoneally to C57BL/6 mice, and animals were subjected to ischemia… CONTINUE READING

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