Selective small molecule angiotensin II type 2 receptor antagonists for neuropathic pain: preclinical and clinical studies.

@article{Smith2016SelectiveSM,
  title={Selective small molecule angiotensin II type 2 receptor antagonists for neuropathic pain: preclinical and clinical studies.},
  author={Maree T Smith and P. R. Vijai Anand and Andrew C. Rice},
  journal={Pain},
  year={2016},
  volume={157 Suppl 1},
  pages={S33-41}
}
Neuropathic pain affects up to 10% of the general population, but drug treatments recommended for the treatment of neuropathic pain are associated with modest efficacy and/or produce dose-limiting side effects. Hence, neuropathic pain is an unmet medical need. In the past 2 decades, research on the pathobiology of neuropathic pain has revealed many novel pain targets for use in analgesic drug discovery programs. However, these efforts have been largely unsuccessful as molecules that showed… CONTINUE READING
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