Selective silencing of DNA-specific B lymphocytes delays lupus activity in MRL/lpr mice.

@article{Tchorbanov2007SelectiveSO,
  title={Selective silencing of DNA-specific B lymphocytes delays lupus activity in MRL/lpr mice.},
  author={Andrey I Tchorbanov and Elisaveta N. Voynova and Nikolina M Mihaylova and Todor A. Todorov and Maria Nikolova and Vihra M Yomtova and Bor-Luen Chiang and Tchavdar L. Vassilev},
  journal={European journal of immunology},
  year={2007},
  volume={37 12},
  pages={3587-96}
}
The pathological DNA-specific B lymphocytes in lupus are logical targets for a selected therapeutic intervention. We have hypothesized that it should be possible to suppress selectively the activity of these B cells in lupus mice by administering to them an artificial molecule that cross-links their surface immunoglobulins with the inhibitory FcgammaIIb surface receptors. A hybrid molecule was constructed by coupling the DNA-mimicking DWEYSVWLSN peptide to a monoclonal anti-mouse FcgammaRIIb… CONTINUE READING

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