Selective serotonin reuptake inhibitors in the treatment of affective disorders--III. Tolerability, safety and pharmacoeconomics.

@article{Goldstein1998SelectiveSR,
  title={Selective serotonin reuptake inhibitors in the treatment of affective disorders--III. Tolerability, safety and pharmacoeconomics.},
  author={Bradley J Goldstein and Paul J Goodnick},
  journal={Journal of psychopharmacology},
  year={1998},
  volume={12 3 Suppl B},
  pages={S55-87}
}
The clinical use of tricyclic antidepressants (TCAs) is often complicated by toxicity and safety problems due to their effects on multiple mechanisms of action, many of which are unnecessary for therapeutic effect. The development of the selective serotonin reuptake inhibitors (SSRIs), with their selective mode of action, has resulted in a class of antidepressant drugs possessing an improved side-effect profile, while retaining good clinical efficacy. Their introduction into clinical practice… CONTINUE READING
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