Selective serotonin reuptake inhibitors and brain hemorrhage: a meta-analysis.

@article{Hackam2012SelectiveSR,
  title={Selective serotonin reuptake inhibitors and brain hemorrhage: a meta-analysis.},
  author={Daniel G. Hackam and Marko Mrkobrada},
  journal={Neurology},
  year={2012},
  volume={79 18},
  pages={
          1862-5
        }
}
OBJECTIVE We synthesized the epidemiologic evidence concerning selective serotonin reuptake inhibitor (SSRI) exposure and the risk of CNS hemorrhage. METHODS We searched for controlled observational studies comparing SSRI therapy with a control group not receiving SSRIs. We used DerSimonian and Laird fixed effect models to compute summary risk associations. RESULTS Intracranial hemorrhage was related to SSRI exposure in both unadjusted (rate ratio [RR] 1.48, 95% confidence interval [CI] 1… CONTINUE READING

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