Selective serotonin reuptake inhibitors and brain hemorrhage

  title={Selective serotonin reuptake inhibitors and brain hemorrhage},
  author={D. Hackam and M. Mrkobrada},
  pages={1862 - 1865}
  • D. Hackam, M. Mrkobrada
  • Published 2012
  • Medicine
  • Neurology
  • Objective: We synthesized the epidemiologic evidence concerning selective serotonin reuptake inhibitor (SSRI) exposure and the risk of CNS hemorrhage. Methods: We searched for controlled observational studies comparing SSRI therapy with a control group not receiving SSRIs. We used DerSimonian and Laird fixed effect models to compute summary risk associations. Results: Intracranial hemorrhage was related to SSRI exposure in both unadjusted (rate ratio [RR] 1.48, 95% confidence interval [CI] 1.22… CONTINUE READING
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      Statistical analysis: Dr. Hackam. Study supervision or coordination: Dr. Hackam
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