Selective serotonin reuptake inhibitors and brain hemorrhage

@article{Hackam2012SelectiveSR,
  title={Selective serotonin reuptake inhibitors and brain hemorrhage},
  author={Daniel G. Hackam and Marko Mrkobrada},
  journal={Neurology},
  year={2012},
  volume={79},
  pages={1862 - 1865}
}
Objective: We synthesized the epidemiologic evidence concerning selective serotonin reuptake inhibitor (SSRI) exposure and the risk of CNS hemorrhage. Methods: We searched for controlled observational studies comparing SSRI therapy with a control group not receiving SSRIs. We used DerSimonian and Laird fixed effect models to compute summary risk associations. Results: Intracranial hemorrhage was related to SSRI exposure in both unadjusted (rate ratio [RR] 1.48, 95% confidence interval [CI] 1.22… Expand
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TLDR
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SSRIs associated with increased risk of brain haemorrhage, but absolute risks low
TLDR
The clinical implication of the study is that the small increase in risk of ICH should not preclude the use of SSRIs in the general population, and Hackam and colleagues suggest theUse of non-SSRI drugs in high-risk patients. Expand
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lective serotonin reuptake inhibitors and the risk of bleed
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Statistical analysis: Dr. Hackam. Study supervision or coordination: Dr. Hackam
  • Statistical analysis: Dr. Hackam. Study supervision or coordination: Dr. Hackam