Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells.

@article{Isaac2018SelectiveSR,
  title={Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells.},
  author={Roi Isaac and Sigalit Boura-Halfon and Diana Gurevitch and A. M. Shainskaya and Yechiel Levkovitz and Yehiel Zick},
  journal={The Journal of biological chemistry},
  year={2018},
  volume={293 12},
  pages={
          4577-4578
        }
}
Background: Selective serotonin reuptake inhibitors (SSRIs) are used for the treatment of mood and anxiety disorders. Results: SSRIs inhibit insulin action and secretion, promote the unfolded protein response, and induce apoptosis of pancreatic cells. Conclusion: SSRIs inhibit insulin signaling and beta cell function. Significance: SSRIs might accelerate the transition from an insulin-resistant state to overt diabetes. 
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