Selective serotonin reuptake inhibitor treatment and risk of fractures: a meta-analysis of cohort and case–control studies

@article{Wu2011SelectiveSR,
  title={Selective serotonin reuptake inhibitor treatment and risk of fractures: a meta-analysis of cohort and case–control studies},
  author={Q. Wu and A. F. Bencaz and Joseph G. Hentz and Michael D Crowell},
  journal={Osteoporosis International},
  year={2011},
  volume={23},
  pages={365-375}
}
SummaryStudies on use of selective serotonin reuptake inhibitors (SSRIs) and risk of fracture have yielded inconsistent results. This meta-analysis, which pooled results from 13 qualifying cohort and case–control studies, found that SSRIs were associated with a significantly increased risk of fractures.IntroductionThis study was conducted to assess whether people who take SSRIs are at an increased risk of fracture.MethodsWe conducted a meta-analysis of observational studies. Relevant studies… Expand
Alliance between selective serotonin reuptake inhibitors and fracture risk: an updated systematic review and meta-analysis
TLDR
It is suggested that SSRIs may be associated with an increased fracture risk; hence, bone health should be taken into consideration while prescribing this class of drugs. Expand
Tricyclic antidepressant use and risk of fractures: A meta‐analysis of cohort and case‐control studies
TLDR
It is indicated that treatment with TCAs may convey an increased risk of fracture, independent of depression and bone mineral density. Expand
Tricyclic Antidepressant Use and Risk of Fractures: A Meta-Analysis of Cohort Studies through the Use of both Frequentist and Bayesian Approaches
TLDR
Overall, TCA use was associated with a significantly increased risk of fracture in both the frequentist approach and the Bayesian method; this results were consistent in multiple sensitivity and subgroup analyses. Expand
Bone: SSRIs associated with fracture risk
  • J. Osorio
  • Medicine
  • Nature Reviews Endocrinology
  • 2011
TLDR
A meta-analysis of cohort and case–control studies in which the occurrence of fractures and/or BMD values were compared between patients receiving or not receiving an SSRI found the risk of fracture was significantly increased in patients taking SSRIs. Expand
Zolpidem use and risk of fractures: a systematic review and meta-analysis
TLDR
Clinicians should be cautious when prescribing zolpidem for patients at high risk of fracture, and high-quality subgroups (cohort studies, high NOS score, adjusted for any confounder, or adjusted for osteoporosis) had higher RRs than the corresponding low- quality subgroups. Expand
Lithium use and risk of fracture: a systematic review and meta-analysis of observational studies
TLDR
It is demonstrated that lithium use was associated with a significant decreased risk of fracture and neither significant heterogeneity nor significant publication bias was observed. Expand
Do Selective Serotonin Reuptake Inhibitors (SSRIs) Cause Fractures?
TLDR
A strong, consistent, and temporal relationship between SSRIs and fractures is found, which appears to follow a biological gradient, however, specificity and biological plausibility remain concerns. Expand
Effect of selective serotonin reuptake inhibitors on bone mineral density: a systematic review and meta-analysis
TLDR
It is demonstrated that the use of SSRIs was significantly associated with lower BMD values of the lumbar spine, but not of the total hip and femoral neck, and SSRI use was associated with a greater bone loss in older people. Expand
The effect of selective serotonin re-uptake inhibitors on risk of type II diabetes mellitus and acute pancreatitis: a meta-analysis
TLDR
Evidence of a significant positive association between SSRIs use and risks of T2DM or AP is provided, and duration of 2 weeks of SSRI use has higher risk of AP, which should be paid much attention to. Expand
Patterns of selective serotonin reuptake inhibitor use and risk of falls and fractures in community-dwelling elderly people: the Three-City cohort
TLDR
In this large community-dwelling elderly sample, SSRI users were at higher risk of falls and fractures, and this association was not due to reverse causality or residual depressive symptoms. Expand
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