Selective serotonin 5-HT2A receptor antagonist EMD 281014 improves delayed matching performance in young and aged rhesus monkeys

@article{Terry2004SelectiveS5,
  title={Selective serotonin 5-HT2A receptor antagonist EMD 281014 improves delayed matching performance in young and aged rhesus monkeys},
  author={Alvin V. Terry and Jerry J. Buccafusco and Gerd D. Bartoszyk},
  journal={Psychopharmacology},
  year={2004},
  volume={179},
  pages={725-732}
}
RationaleThe superior cognitive effects of atypical neuroleptics over typical agents reported in the schizophrenia literature are often attributed to the more prominent antagonist activity of the atypical drugs at serotonin 5HT2A receptors. However, atypical neuroleptics also have activity at many additional neurotransmitter receptors and few studies have specifically (and prospectively) tested the hypothesis that 5HT2A antagonism alone results in enhanced cognitive function.ObjectivesThe… 
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