Selective sequestration of X4 isolates by human genital epithelial cells: Implication for virus tropism selection process during sexual transmission of HIV

@article{Berlier2005SelectiveSO,
  title={Selective sequestration of X4 isolates by human genital epithelial cells: Implication for virus tropism selection process during sexual transmission of HIV},
  author={W. Berlier and T. Bourlet and P. Lawrence and Hind Hamzeh and C. Lambert and C. Genin and B. Verrier and M. Dieu-Nosjean and B. Pozzetto and O. Del{\'e}zay},
  journal={Journal of Medical Virology},
  year={2005},
  volume={77}
}
X4 and R5 HIV strains are present in the semen of men infected with HIV but R5 isolates are transmitted preferentially. The role of human epithelial cells in this selection is addressed. Three human cervical cell lines—CaSki, SiHa, and HEC1A—and normal human vaginal cells from HIV‐negative donors were characterized for HIV receptor expression and incubated with X4 and R5 laboratory‐adapted strains or primary isolates. The infection was assessed by detection of intracellular HIV DNA. The three… Expand
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