Selective rescue of selenoprotein expression in mice lacking a highly specialized methyl group in selenocysteine tRNA.

@article{Carlson2005SelectiveRO,
  title={Selective rescue of selenoprotein expression in mice lacking a highly specialized methyl group in selenocysteine tRNA.},
  author={Bradley A. Carlson and Xueming Xu and Vadim N. Gladyshev and Dolph Lee Hatfield},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 7},
  pages={5542-8}
}
Selenocysteine (Sec) is the 21st amino acid in the genetic code. Its tRNA is variably methylated on the 2'-O-hydroxyl site of the ribosyl moiety at position 34 (Um34). Herein, we identified a role of Um34 in regulating the expression of some, but not all, selenoproteins. A strain of knock-out transgenic mice was generated, wherein the Sec tRNA gene was replaced with either wild type or mutant Sec tRNA transgenes. The mutant transgene yielded a tRNA that lacked two base modifications, N(6… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 46 extracted citations

Selenoproteins and maternal nutrition.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology • 2008
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.

Selective Rescue of Selenoproteins

C. H. Yeung, A. Wagenfeld, E. Nieschlag, T. G. Cooper
Biol. Reprod • 2000

Similar Papers

Loading similar papers…