Selective repression by Fis and H-NS at the Escherichia coli dps promoter.

  title={Selective repression by Fis and H-NS at the Escherichia coli dps promoter.},
  author={David C Grainger and Martin D. Goldberg and David J. Lee and Stephen J W Busby},
  journal={Molecular microbiology},
  volume={68 6},
Dps is a nucleoid-associated protein that plays a major role in condensation of the Escherichia coli chromosome in stationary phase. Here we show that two other nucleoid-associated proteins, Fis and H-NS, can bind at the dps gene promoter and downregulate its activity. Both Fis and H-NS selectively repress the dps promoter, preventing transcription initiation by RNA polymerase containing sigma(70), the housekeeping sigma factor, but not by RNA polymerase containing sigma(38), the stationary… CONTINUE READING

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