Selective replication of transformation-defective avian sarcoma virus mutants in duck embryo fibroblasts.

@article{Shimakage1979SelectiveRO,
  title={Selective replication of transformation-defective avian sarcoma virus mutants in duck embryo fibroblasts.},
  author={Misuzu Shimakage and Toshio Kamahora and Akira Hakura and Kumao Toyoshima},
  journal={The Journal of general virology},
  year={1979},
  volume={45 1},
  pages={99-105}
}
When an avian sarcoma virus (ASV), subgroup C Bratislava 77 (B77-C) was inoculated into duck embryo fibroblast cultures (DEF) at a m.o.i. of 0.02, its replication was retarded by about 3 days compared with that in chick embryo fibroblast cultures (CEF). A transformation-defective (td) mutant was isolated during this period of retardation. Unlike the sarcoma virus, this td mutant replicated in both DEF and CEF with no retardation, even at a low m.o.i. The subgroup C Prague strain of Rous sarcoma… CONTINUE READING