Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII.

@article{Fink2003SelectiveRO,
  title={Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII.},
  author={Charles C Fink and K. Ulrich Bayer and J. Wickham Myers and James E Ferrell and Howard F Schulman and Tobias Balthasar Meyer},
  journal={Neuron},
  year={2003},
  volume={39 2},
  pages={
          283-97
        }
}
Neurite extension and branching are important neuronal plasticity mechanisms that can lead to the addition of synaptic contacts in developing neurons and changes in the number of synapses in mature neurons. Here we show that Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates movement, extension, and branching of filopodia and fine dendrites as well as the number of synapses in hippocampal neurons. Only CaMKIIbeta, which peaks in expression early in development, but not CaMKIIalpha… CONTINUE READING

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