Selective regulation of multidrug resistance protein in vascular smooth muscle cells by the isoquinoline alkaloid coptisine.

@article{Suzuki2010SelectiveRO,
  title={Selective regulation of multidrug resistance protein in vascular smooth muscle cells by the isoquinoline alkaloid coptisine.},
  author={Hiroka Suzuki and Hiroki C. Tanabe and Hajime Mizukami and Makoto Inoue},
  journal={Biological & pharmaceutical bulletin},
  year={2010},
  volume={33 4},
  pages={677-82}
}
When the biological activites of hydrophobic drugs or xenobiotics are studied, it is important to clarify their effects on expression and function of multidrug resistance (MDR) protein. We therefore evaluated the effects of coptisine on MDR in comparison with the structurally related isoquinoline alkaloids berberine and palmatine. To achieve this, we investigated the effects of the three alkaloids on the expression and function of P-glycoprotein/MDR1, MDR1 gene products, in vascular smooth… CONTINUE READING

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