Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain

  title={Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain},
  author={Andrew J. Bannister and P. Zegerman and J. F. Partridge and E. Miska and J. Thomas and R. Allshire and T. Kouzarides},
  • Andrew J. Bannister, P. Zegerman, +4 authors T. Kouzarides
  • Published 2001
  • Biology, Medicine
  • Nature
  • Heterochromatin protein 1 (HP1) is localized at heterochromatin sites where it mediates gene silencing. The chromo domain of HP1 is necessary for both targeting and transcriptional repression. In the fission yeast Schizosaccharomyces pombe, the correct localization of Swi6 (the HP1 equivalent) depends on Clr4, a homologue of the mammalian SUV39H1 histone methylase. Both Clr4 and SUV39H1 methylate specifically lysine 9 of histone H3 (ref. 6). Here we show that HP1 can bind with high affinity to… CONTINUE READING
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