Selective reactivities of isocyanates towards DNA bases and genotoxicity of methylcarbamoylation of DNA.

@article{Tamura1992SelectiveRO,
  title={Selective reactivities of isocyanates towards DNA bases and genotoxicity of methylcarbamoylation of DNA.},
  author={Naoaki Tamura and Kazunori Aoki and Mi Sun Lee},
  journal={Mutation research},
  year={1992},
  volume={283 2},
  pages={97-106}
}
The reactivities of methyl isocyanate (MIC) and phenyl isocyanate (PIC) with DNA, and the genotoxicity of MIC were investigated. MIC and PIC reacted with the exocyclic amino group of deoxycytidine, deoxyadenosine and deoxyguanosine to produce carbamoylated products. The reactions of both isocyanates with deoxycytidine were 2 and 4 orders of magnitude higher than with deoxyadenosine and deoxyguanosine, respectively. To explore the genotoxicity of MIC, M13mp9 RF DNA was modified with MIC and then… CONTINUE READING

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