Selective pulmonary artery perfusion for the treatment of primary lung cancer: Improved drug exposure of the lung.

@article{Putte2009SelectivePA,
  title={Selective pulmonary artery perfusion for the treatment of primary lung cancer: Improved drug exposure of the lung.},
  author={Bart Pieter Van Putte and Marco J J H Grootenboers and Wim-Jan P van Boven and Maikel van Oosterhout and G. Pasterkamp and Gert Folkerts and F. M. N. H. Schramel},
  journal={Lung cancer},
  year={2009},
  volume={65 2},
  pages={208-13}
}
INTRODUCTION Selective pulmonary artery perfusion (SPAP) is an experimental drug infusion method for the treatment of lung cancer that aims to achieve more effective T(umour) and lymph N(ode) down-staging. The aim of this experiment was to compare drug uptake of gemcitabine and carboplatin during SPAP and intravenous infusion (IV). MATERIAL AND METHODS SPAP was performed in 12 pigs using clinically applied doses of gemcitabine (1.25g/m(2), n=4) and carboplatin (AUC 5, n=4) and a combination… CONTINUE READING