Selective protein covalent binding and target organ toxicity.

@article{Cohen1997SelectivePC,
  title={Selective protein covalent binding and target organ toxicity.},
  author={Steven D. Cohen and Neil R. Pumford and Edward A. Khairallah and Kim Boekelheide and Lance R. Pohl and Hamid R. Amouzadeh and Jack A. Hinson},
  journal={Toxicology and applied pharmacology},
  year={1997},
  volume={143 1},
  pages={
          1-12
        }
}
Protein covalent binding by xenobiotic metabolites has long been associated with target organ toxicity but mechanistic involvement of such binding has not been widely demonstrated. Modern biochemical, molecular, and immunochemical approaches have facilitated identification of specific protein targets of xenobiotic covalent binding. Such studies have revealed that protein covalent binding is not random, but rather selective with respect to the proteins targeted. Selective binding to specific… CONTINUE READING
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