Selective protein arylation and acetaminophen-induced hepatotoxicity.

@article{Cohen1997SelectivePA,
  title={Selective protein arylation and acetaminophen-induced hepatotoxicity.},
  author={Steven D. Cohen and Edward A. Khairallah},
  journal={Drug metabolism reviews},
  year={1997},
  volume={29 1-2},
  pages={
          59-77
        }
}
More than 20 years have passed since the early reports of acute hepatotoxicity with APAP overdose. During that period investigative research to discover the "mechanism" underlying the toxicity has been conducted in many species and strains of intact animals as well as in a variety of in vitro and culture systems. Such work has clarified the primary role of biotransformation and the protective role of GSH. Understanding the former provides explanations for the toxic interactions which may occur… CONTINUE READING
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