Selective protection of methionine enkephalin released from brain slices by enkephalinase inhibition.

@article{Patey1981SelectivePO,
  title={Selective protection of methionine enkephalin released from brain slices by enkephalinase inhibition.},
  author={Gilles Patey and S R de la Baume and Jean Charles Schwartz and Claude Gros and B Roques and Marie-Claude Fourni{\'e}-Zaluski and E Soroca-Lucas},
  journal={Science},
  year={1981},
  volume={212 4499},
  pages={1153-5}
}
Methionine enkephalin release was evoked by depolarization of slices from rat striatum with potassium. In the presence of 0.1 microM thiorphan [(N(R,S)-3-mercapto-2-benzylpropionyl)glycine], a potent inhibitor of enkephalin dipeptidyl carboxypeptidase (enkephalinase), the recovery of the pentapeptide in the incubation medium was increased by about 100 percent. A similar effect was observed with the dipeptide phenylalanylalanine, a selective although less potent enkephalinase inhibitor… CONTINUE READING
12 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…