Selective protection against the cytotoxicity of methotrexate and methotrexate-poly(lysine) by thiamine pyrophosphate, heparin and leucovorin.

@article{Shen1981SelectivePA,
  title={Selective protection against the cytotoxicity of methotrexate and methotrexate-poly(lysine) by thiamine pyrophosphate, heparin and leucovorin.},
  author={W. Shen and H. J. Ryser},
  journal={Life sciences},
  year={1981},
  volume={28 11},
  pages={
          1209-14
        }
}
  • W. Shen, H. J. Ryser
  • Published 1981
  • Chemistry, Medicine
  • Life sciences
  • Abstract The cytotoxicity of both methotrexate (MTX) and methotrexate-poly(L-lysine) conjugate (MTX-poly(lys)) on L929 mouse fibroblasts can be prevented by the simultaneous administration of Leucovorin. Thiamine pyrophosphate, an inhibitor for MTX-transport, protects cells from the toxicity of MTX, but not of MTX-poly(lys). Heparin at low concentration (1 μg/m1) completely abolishes the toxic effect of MTX-poly(lys), but not of MTX. These results suggest that although MTX and MTX-poly(lys… CONTINUE READING