Selective proapoptotic activity of a secreted recombinant antibody/AIF fusion protein in carcinomas overexpressing HER2

Abstract

Apoptosis-inducing factor (AIF) represents a caspase-independent apoptotic pathway in the cell, and a mitochondrial localization sequence-truncated AIF (AIFΔ1–120) can be relocated from the cytoplasm to the nucleus and exhibit a constitutive proapoptotic activity. Here, we generated a chimeric immuno-AIF protein, which comprised an HER2 antibody, a… (More)
DOI: 10.1038/sj.gt.3302672

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@article{Yu2006SelectivePA, title={Selective proapoptotic activity of a secreted recombinant antibody/AIF fusion protein in carcinomas overexpressing HER2}, author={C H Yu and L Jia and Y L Meng and Jingwei Zhao and Yafei Zhang and X P Qiu and Y M Xu and W-H Wen and L Q Yao and D S Fan and B Q Jin and S R Chen and A G Yang}, journal={Gene Therapy}, year={2006}, volume={13}, pages={313-320} }