Selective proapoptotic activity of a secreted recombinant antibody/AIF fusion protein in carcinomas overexpressing HER2

@article{Yu2006SelectivePA,
  title={Selective proapoptotic activity of a secreted recombinant antibody/AIF fusion protein in carcinomas overexpressing HER2},
  author={C Yu and L I Jia and Y-L Meng and J. Zhao and Y Zhang and X-C Qiu and Y Xu and W Wen and L-b Yao and D. M. Fan and B-Q Jin and S Chen and A F Yang},
  journal={Gene Therapy},
  year={2006},
  volume={13},
  pages={313-320}
}
Apoptosis-inducing factor (AIF) represents a caspase-independent apoptotic pathway in the cell, and a mitochondrial localization sequence-truncated AIF (AIFΔ1–120) can be relocated from the cytoplasm to the nucleus and exhibit a constitutive proapoptotic activity. Here, we generated a chimeric immuno-AIF protein, which comprised an HER2 antibody, a… CONTINUE READING